Efferocytosis-associated transcriptomic patterns characterize prognosis and immune landscape in osteosarcoma
We established an efferocytosis-related prognostic signature and elucidated its underlying mechanism wherein MAGEA11 promoted immunosuppression via a Gas6-MERTK/AXL-dependent efferocytosis circuit. This integrated study positions efferocytosis as a key driver of the OS microenvironment and a promising target for clinical intervention.
Authors
- Xueliang Song
- Fei Wang (ORCID: https://orcid.org/0000-0001-6712-3468)
- Jiahong Shen
- Li Li
- Ru Wang
- Xiaofan Tou
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of bone oncology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.jbo.2026.100743
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00