Comparative Effectiveness of Current Glucose-lowering Medications in Type 2 Diabetes Mellitus: Emulation of a Modified GRADE Trial
In this target trial emulation, GLP-1RAs were most effective for glycemic control, aligning with GRADE, and superior to SGLT-2is in combination with metformin for T2DM in patients with low-to-moderate cardiovascular risk.
Authors
- Georg Hahn
- Elisabetta Patorno (ORCID: https://orcid.org/0000-0002-8809-9898)
- Avik Ray (ORCID: https://orcid.org/0000-0003-0511-240X)
- D. Wexler
- Sara J. Cromer
- Robert J. Glynn
- Sushama K. Sreedhara
- Julie M. Paik
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- VA Boston Healthcare System (US)
- Massachusetts General Hospital (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Journal of General Internal Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1007/s11606-026-10170-7
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Diabetes Association
- Brigham and Women's Hospital
- Patient-Centered Outcomes Research Institute