18F-FDG PET/MR reveals specific brain metabolic features in Parkinson’s disease with frailty
Frailty in PD is associated with advanced age, greater motor severity, and possibly increased medication needs. Frail PD patients exhibit specific patterns of cerebral hypometabolism and more severe cognitive deficits. Distinct brain regions are differentially associated with specific cognitive domains. Notably, reduced metabolism in the Temporal_Inf_R is significantly related to motor symptom severity in frail PD, suggesting a key region in the pathophysiology of frailty in PD.
Authors
- Fengju Mao
- Chang Sun
- Wenli Zhang (ORCID: https://orcid.org/0000-0001-9077-4189)
- Xin Luo (ORCID: https://orcid.org/0000-0002-1740-2765)
- Lu Liu (ORCID: https://orcid.org/0000-0001-9252-9101)
- Guoyang Li Guoyang Li
- Hong Zhao
- Yang Yang
- Long Zhao
Institutions
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- United Imaging Healthcare (China) (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fnagi.2025.1624203
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00