Case Report of Concomitant Pleuropulmonary Blastoma and Hepatoblastoma in a 25-Month-Old Child With a Germline <i>DICER1</i> Pathogenic Variant
Pleuropulmonary blastoma and hepatoblastoma are 2 well-recognized embryonal tumors of the thorax and liver respectively occurring in children. The simultaneous presentation of 2 or more pediatric embryonal tumors in the same patient is extremely rare. Specifically, cases of concomitant pleuropulmonary blastoma and hepatoblastoma in the same patient are extremely rare with only a single clinical case report published thus far. We report a case of a 25-month-old boy presenting with concomitant pleuropulmonary blastoma and hepatoblastoma, and describe the clinical, imaging, and histopathological findings. We additionally describe the underlying <i>DICER1</i> alterations in both tumors. This is the first case described in Vietnam and only the second such case reported globally.
Authors
- Jian Yuan Goh (ORCID: https://orcid.org/0000-0003-4562-7475)
- Lan N. Bui (ORCID: https://orcid.org/0000-0001-9048-8094)
- Thach Ngoc Hoang
- Diep Hong Pho
- Kenneth Tou En Chang
- Ngoc Thi Kim Le
Institutions
- KK Women's and Children's Hospital (SG)
- Duke-NUS Medical School (SG)
- Vietnam National Children's Hospital (VN)
Publication Details
- Journal
- Pediatric and Developmental Pathology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1177/10935266251413978
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00