Anti-CENP-B polarity divides SLE: divergent clinical-immune phenotypes and distinct treatment responses
Anti-CENP-B positivity defines a distinct SLE subset characterized by older age at onset, milder renal involvement, Raynaud's phenomenon, and specific humoral alterations; importantly, these patients also show a treatment response that differs significantly from that of the anti-CENP-B-negative group, underscoring the imperative for personalized, precision therapy.
Authors
- Tian Xia
- Yuxing Yao
- Youhua Yuan
- Zhefeng Xiao
- Jianfeng Li (ORCID: https://orcid.org/0000-0003-2349-208X)
- Xiaoli liu
- Lemei An
- Xia Zhang
- Xiuzhi Zhang
Institutions
- Berkeley College (US)
- National Clinical Research (US)
- Henan Provincial People's Hospital (CN)
- Henan Forestry Vocational College (CN)
- University of California, Berkeley (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fimmu.2026.1762899
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China