Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species

Genomic relatedness amongst clustered isolates was confirmed in this first fluconazole-resistant <i>C. parapsilosis</i> outbreak in Australia. Fluconazole-resistant isolates harboured <i>ERG11</i> Y132F and <i>TAC1</i> D444Y mutations. The protracted outbreak underscores the need to prioritise enhanced surveillance.

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Journal
Frontiers in Microbiology
Published
2026-01-21
DOI
https://doi.org/10.3389/fmicb.2025.1742871
Primary Topic
Antifungal resistance and susceptibility
Type
article
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article

Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species

Manoshi Perera, Kerry Weeks
Frontiers in Microbiology
Antifungal resistance and susceptibility
article

Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species

Manoshi Perera, Kerry Weeks
article en

Abstract

Genomic relatedness amongst clustered isolates was confirmed in this first fluconazole-resistant <i>C. parapsilosis</i> outbreak in Australia. Fluconazole-resistant isolates harboured <i>ERG11</i> Y132F and <i>TAC1</i> D444Y mutations. The protracted outbreak underscores the need to prioritise enhanced surveillance.

Frontiers in MicrobiologyVol. 16
The University of Sydney (AU), Curtin University (AU), Royal Prince Alfred Hospital (AU), Royal North Shore Hospital (AU), Taronga Conservation Society Australia (AU), North Shore Hospital (NZ), Westmead Hospital (AU), Reserve Bank of Australia (AU), Chemring Countermeasures (United Kingdom) (GB), Westerdijk Fungal Biodiversity Institute (NL), Infectious Diseases Institute (UG), Northern Sydney Local Health District (AU), Westmead Institute for Medical Research (AU), Universidad del Rosario (CO)
Life in Land
Openalex Percentile: Top 79%
Antifungal resistance and susceptibility
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Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species — Manoshi Perera, Kerry Weeks · Frontiers in Microbiology (2026) | TGRS Research Map | TGRS