Outcome of Prostaglandin E1 Therapy in Critical Lower Limb Ischemia

PGE1 therapy showed meaningful clinical benefit in patients with CLI by relieving pain, improving claudication, promoting ulcer healing, and supporting limb salvage, even when objective perfusion gains were limited. These findings underscore its value as a practical therapeutic option in resource-limited settings and highlight the need for further studies to refine and optimize treatment strategies.

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Publication Details

Journal
Cureus
Published
2026-01-21
DOI
https://doi.org/10.7759/cureus.102025
Primary Topic
Peripheral Artery Disease Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Outcome of Prostaglandin E1 Therapy in Critical Lower Limb Ischemia

Rajan Karmakar, Samaresh Chandra Saha, T.U. KHAN, Masnoon Ahmed Noor et al.
Cureus
Peripheral Artery Disease Management
article

Outcome of Prostaglandin E1 Therapy in Critical Lower Limb Ischemia

Rajan Karmakar, Samaresh Chandra Saha, T.U. KHAN, Masnoon Ahmed Noor, M. D. A Hossain, M. D. Mezbahur Rahman, Mohammad Merajul Islam, Muhammed I Khalilullah
article en

Abstract

PGE1 therapy showed meaningful clinical benefit in patients with CLI by relieving pain, improving claudication, promoting ulcer healing, and supporting limb salvage, even when objective perfusion gains were limited. These findings underscore its value as a practical therapeutic option in resource-limited settings and highlight the need for further studies to refine and optimize treatment strategies.

CureusVol. 18(1)
Bangladesh University (BD), University of Dhaka (BD), Bangladesh Bank (BD), National Institute of Cardiovascular Diseases (BD), Directorate General of Health Services (BD)
Reduced inequalities
Openalex Percentile: Top 81%
Peripheral Artery Disease Management
DOIOpen Access PDFOpenAlex
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Outcome of Prostaglandin E1 Therapy in Critical Lower Limb Ischemia — Rajan Karmakar, Samaresh Chandra Saha, et al. · Cureus (2026) | TGRS Research Map | TGRS