Diagnostic accuracy of urinary lipoarabinomannan antigen detection for the diagnosis of pulmonary and extra pulmonary tuberculosis (EPTB) in HIV negative population

Urine LAM performed better than previously reported in HIV-negative populations but remains suboptimal as a point-of-care test. This study showed higher sensitivity and PPV for pulmonary TB in MRS smear-positive cases, better specificity and NPV for extrapulmonary TB, good performance in smear-negative extrapulmonary TB, and promising utility in unconfirmed TB.