Synthesis of Tetrahydroisoquinolinoquinolines via Sequential Pd-Catalyzed N-Arylation and Pd-Catalyzed Alkene Carboamination Reactions

Abstract The synthesis of substituted tetrahydroisoquinolinoquinolines via a two-step route involving a Pd-catalyzed N-arylation reaction followed by a Pd-catalyzed alkene carboamination reaction is described. The combined transformations lead to the generation of two rings and three bonds (two C–N and one C–C) and the heterocyclic products are obtained in moderate to good yields.