Catalytic Hydrophosphorylation of Propiolates and Three-Component Phosphorylation of Aldehydes
A practical and efficient regio- and stereoselective hydrophosphorylation of propiolates, as well as a multicomponent reaction incorporating an aldehyde component, is reported. Both processes proceed with atom economy in very straightforward experimental procedures. The reactions are catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane) and use readily available H-phosphonates as the phosphorylating agent.
Authors
- Jimena Scoccia (ORCID: https://orcid.org/0000-0001-9296-3071)
- Samuel Delgado‐Hernández (ORCID: https://orcid.org/0000-0001-9952-6480)
- David Tejedor (ORCID: https://orcid.org/0000-0003-3262-0776)
- Romen Carrillo
- Alejandro Peixoto de Abreu Lima
- Eva M Martín-Díaz
Institutions
- Universidad de la República de Uruguay (UY)
- Instituto de Productos Naturales y Agrobiología (ES)
- Institut Pasteur de Montevideo (UY)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1021/acs.joc.5c02398
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00