Optimizing expanded carrier screening for China: Multi-center study establishes 202-gene panel with optimal cost-effectiveness in preconception and prenatal care
For Chinese couples, the 202-gene panel (Panel C) is the most cost-effective option in both preconception and prenatal settings. However, for couples prioritizing comprehensive screening over cost, the 222-gene panel (Panel A) provides greater clinical value at a higher cost.
Authors
- Y. D. Hang (ORCID: https://orcid.org/0000-0003-1067-583X)
- Zhaolian Wei
- Jing Yuan
- WeiSheng Cheng
- Yunxia Cao
- Yulu Yang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1371/journal.pone.0338642
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- National Key Research and Development Program of China