Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer

Our study indicates that high CHEK1 expression could be an independent prognostic marker for pancreatic cancer and may drive cancer progression by influencing DNA replication and G2/M checkpoint pathways. These insights offer a foundation for future research and targeted precision therapy involving CHEK1.

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Publication Details

Journal
PLoS ONE
Published
2026-01-21
DOI
https://doi.org/10.1371/journal.pone.0340878
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer

Ruirong Yan, Yaru Jiang, Xiaonan Wei, Haibin Li et al.
PLoS ONE
BRCA gene mutations in cancer
article

Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer

Ruirong Yan, Yaru Jiang, Xiaonan Wei, Haibin Li, Shanshan Wang, Yanping Li
article en

Abstract

Our study indicates that high CHEK1 expression could be an independent prognostic marker for pancreatic cancer and may drive cancer progression by influencing DNA replication and G2/M checkpoint pathways. These insights offer a foundation for future research and targeted precision therapy involving CHEK1.

PLoS ONEVol. 21(1)
Third Affiliated Hospital of Guangzhou Medical University (CN), Shandong Provincial Hospital (CN), Shandong First Medical University (CN), Jining Medical University (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 77%
BRCA gene mutations in cancer
DOIOpen Access PDFOpenAlex
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Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer — Ruirong Yan, Yaru Jiang, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS