Mutational patterns and ancestry-linked profiles in a large hepatocellular carcinoma and combined hepatocellular–cholangiocarcinoma cohort
Our study represents one of the largest cohorts of HCC and cHCC-CCA patients with genomic data and highlights the critical role of integrated molecular diagnostics. Beyond uncovering therapeutic targets, next-generation sequencing profiling offers significant benefits in improving diagnostic accuracy for liver cancer.
Authors
- Stephan Bartels (ORCID: https://orcid.org/0000-0002-8903-2345)
- J.S. Ross
- Anna Lena Saborowski (ORCID: https://orcid.org/0000-0003-4857-4276)
- K. Murugesan
- S. Rengarajan
- A. Vogel
- C. Gerdes
Institutions
- SUNY Upstate Medical University (US)
- Boston Foundation (US)
- Princess Margaret Cancer Centre (CA)
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.esmoop.2025.106048
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00