Case Report: Angioimmunoblastic T-cell lymphoma initially diagnosed as eosinophilic granulomatosis with polyangiitis

This case underscores that AITL can closely mimic EGPA, presenting with severe asthma, hypereosinophilia, sinusitis, and systemic symptoms. It emphasizes the necessity of considering underlying lymphoma in patients with suspected EGPA who show an atypical or refractory course to conventional therapy. A definitive diagnosis often requires an adequate tissue sample, preferably from a surgical lymph node biopsy, to avoid misdiagnosis and ensure appropriate management. Respiratory physicians should maintain a high index of suspicion for lymphoid malignancies in such complex presentations.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-22
DOI
https://doi.org/10.3389/fmed.2025.1716129
Primary Topic
Vascular Tumors and Angiosarcomas
Type
article
Field-Weighted Citation Impact
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article

Case Report: Angioimmunoblastic T-cell lymphoma initially diagnosed as eosinophilic granulomatosis with polyangiitis

Yi Guo, Rui Dai, Jialing Xie, Yong Sun et al.
Frontiers in Medicine
Vascular Tumors and Angiosarcomas
article

Case Report: Angioimmunoblastic T-cell lymphoma initially diagnosed as eosinophilic granulomatosis with polyangiitis

Yi Guo, Rui Dai, Jialing Xie, Yong Sun, Simin Xie, Guochao Shi, Yingmeng Ni
article en

Abstract

This case underscores that AITL can closely mimic EGPA, presenting with severe asthma, hypereosinophilia, sinusitis, and systemic symptoms. It emphasizes the necessity of considering underlying lymphoma in patients with suspected EGPA who show an atypical or refractory course to conventional therapy. A definitive diagnosis often requires an adequate tissue sample, preferably from a surgical lymph node biopsy, to avoid misdiagnosis and ensure appropriate management. Respiratory physicians should maintain a high index of suspicion for lymphoid malignancies in such complex presentations.

Frontiers in MedicineVol. 12
Shanghai Jiao Tong University (CN), Ruijin Hospital (CN)
Good health and well-being
Openalex Percentile: Top 81%
Vascular Tumors and Angiosarcomas
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Case Report: Angioimmunoblastic T-cell lymphoma initially diagnosed as eosinophilic granulomatosis with polyangiitis — Yi Guo, Rui Dai, et al. · Frontiers in Medicine (2026) | TGRS Research Map | TGRS