Light-Mediated g-C <sub>3</sub> N <sub>4</sub> -Catalyzed Anti-Markovnikov Hydroarylation of Enamides: Direct Access to β-Arylethylamine with Nematicidal Activity
Hydroarylation is an efficient strategy for the conversion of unsaturated precursors into functional structural motifs. Herein, with reusable g-C<sub>3</sub>N<sub>4</sub> as the photocatalyst, we disclose a photocatalytic anti<i>-</i>Markovnikov hydroarylation to synthesize β-arylethylamines. The combination of g-C<sub>3</sub>N<sub>4</sub> and thiol facilitates diverse aryl radical addition reactions from aryl(hetero) halide substrates. Scalability and recyclability studies demonstrate the robust efficiency and stability of g-C<sub>3</sub>N<sub>4</sub>, underscoring its industrial potential. Notably, selected derivatives exhibit potent nematicidal activity, representing a promising class of agrochemical candidates.
Authors
- Y. LI
- Qingqiang Tian
- Guangpeng Wang (ORCID: https://orcid.org/0000-0003-0608-1238)
- Bingrui Liu
- Zhenyao Dai
Institutions
- University of Science and Technology of China (CN)
- Anhui Agricultural University (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c05028
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00