BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension
BMP9 plays a protective role against IL-33-induced EndMT in PAECs by upregulating sST2 expression and neutralizing IL-33, suggesting that targeting the IL-33 signaling pathway may represent a promising therapeutic strategy to mitigate EndMT in PAH.
Authors
- Marie‐José Goumans (ORCID: https://orcid.org/0000-0001-9344-6746)
- Robert Szulcek (ORCID: https://orcid.org/0000-0003-0450-7338)
- Clarissa Becher (ORCID: https://orcid.org/0000-0002-1811-8037)
- Rozenn Quarck (ORCID: https://orcid.org/0000-0002-8293-6261)
- Xiaoke Pan
- E. Groeneveld (ORCID: https://orcid.org/0000-0001-6730-1498)
- Frances S. de Man (ORCID: https://orcid.org/0000-0002-5776-7793)
- Beau Neep
- Gonzalo Sanchez-Duffhues
- Ly Tu
- Paul B Yu
- Christophe Guignabert
Institutions
- Brigham and Women's Hospital (US)
- Université Paris-Saclay (FR)
- Leiden University Medical Center (NL)
- Pulmonary Hypertension Association (US)
- Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR)
- Nanomaterials and Nanotechnology Research Center (ES)
- Charité - Universitätsmedizin Berlin (DE)
- Vrije Universiteit Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Hypertension
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1161/hypertensionaha.125.24916
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00