Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England

Maternal and clinical risk factors explain only a fraction of stillbirths in nulliparous women and cannot underpin a clinically useful prediction model. These findings demonstrate the limitations of risk-based screening strategies and highlight the need for integrated approaches that combine maternal characteristics with biochemical, biophysical, and system-level factors to achieve meaningful advances in stillbirth prevention.

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Publication Details

Journal
BMC Medicine
Published
2026-01-22
DOI
https://doi.org/10.1186/s12916-025-04598-7
Primary Topic
Grief, Bereavement, and Mental Health
Type
article
Field-Weighted Citation Impact
0.00

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article

Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England

A. Howell, Viner Russell M, Winter Susan C, S. Cameron J. et al.
BMC Medicine
Grief, Bereavement, and Mental Health
article

Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England

A. Howell, Viner Russell M, Winter Susan C, S. Cameron J., Burden C., Brigante L., Harlev-Lam B., Draycott T., Thilaganathan B., Cheng V., Lenguerrand E., Judge A., Margelyte R., Anumba D.
article en

Abstract

Maternal and clinical risk factors explain only a fraction of stillbirths in nulliparous women and cannot underpin a clinically useful prediction model. These findings demonstrate the limitations of risk-based screening strategies and highlight the need for integrated approaches that combine maternal characteristics with biochemical, biophysical, and system-level factors to achieve meaningful advances in stillbirth prevention.

BMC MedicineVol. 24(1)
Royal College of Obstetricians and Gynaecologists (GB), King's College London (GB), Royal College of Midwives (GB), St George’s University Hospitals NHS Foundation Trust (GB), Southmead Hospital (GB), University of Bristol (GB), University of Sheffield (GB)
National Institute for Health and Care Research, King's College London, Tommy's
Openalex Percentile: Top 83%
Grief, Bereavement, and Mental Health
DOIOpen Access PDFOpenAlex
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Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England — A. Howell, Viner Russell M, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS