Functional dysconnectivity in breast cancer patients undergoing hormone therapy
This study is the first to examine whole-brain rsFC in breast cancer patients undergoing hormone therapy. We found robust hypoconnectivity in patients, which demonstrated modest relationships with cognition. Identifying the pattern by which breast cancer and hormone therapy affect brain networks may aid in the development of therapeutic options for patients experiencing negative effects of hormone therapy, thus improving quality of life for cancer survivors. Further, the detection of abnormal brain function may help characterize treatment-associated neural changes that are not captured by standard cognitive measures.
Authors
- Marko Mihailovic (ORCID: https://orcid.org/0000-0002-9962-4029)
- Eric D. Donnelly (ORCID: https://orcid.org/0000-0001-6028-7128)
- Joel L. Voss (ORCID: https://orcid.org/0000-0003-4180-9335)
- Alexandra C. Apple (ORCID: https://orcid.org/0000-0002-3192-8069)
- Mehmet E. Dokucu (ORCID: https://orcid.org/0000-0002-1720-3467)
- Ilana F. Gareen (ORCID: https://orcid.org/0000-0002-0457-5595)
- Lei Wang (ORCID: https://orcid.org/0000-0002-0664-2704)
- James L. Reilly
- Sonya V. Gupta
- William J. Gradishar
- Julie Petersen
- Derin Cobia
Institutions
- Brigham Young University (US)
- Northwestern University (US)
- University of California, San Francisco (US)
- The Ohio State University Wexner Medical Center (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Wake Forest University (US)
Publication Details
- Journal
- Journal of Clinical and Experimental Neuropsychology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1080/13803395.2026.2617353
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00