Conceptual Insight on Maintaining Oral- Brain axis Through Ayurveda Intervention

Introduction: Oral health and cognitive health are intricately connected. The health of our teeth, gums, and oral cavity have a direct influence on the health of our brain. The brain and oral connection are quite profound emerging evidence suggests a significant link between the oral microbiome and neuropsychiatric disorders, including depression Methods and Materials: A literature review was collected using databases, to examining the connection between oral microbiota and depression. So, when we have poor oral care which eventually results in mental function disabilities like anxiety and depression. Studies states that the composition of the salivary microbiome like Spirochaetaceae, Actinomyces were found to be associated with severity of depressive and anxiety symptoms in adolescents. This indicates that oral microbes can travel up into the brain. Review in classics explains about the Gandusha and Kavala procedure which concentrate more on the oral health can be linked to evaluate the efficacy in modulating oral flora and improving mental health. Results: Gandusha and Kavala is other form of drug administration into the oral cavity in which the active ingredients and chemical constituents of the drug are absorbed through the buccal mucosa and reach the blood stream. Discussion: Studies that have looked at the brain of Alzheimer’s patients during autopsies have actually found oral pathogens present in brain tissue. Gandusha and Kavala may serve as adjunctive tools in the prevention and management of depression by targeting upstream factors such as oral dysbiosis. Oral therapies not only support oral hygiene but may also reduce neuroinflammatory signals implicated in mood disorders via the oral-gut-brain axis. Conclusion: The Oral Gut Brain Axis linked with Gandusha and Kavala procedure using offer promising, low-cost preventive strategies that support microbial balance and mental wellness.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-22
DOI
https://doi.org/10.5281/zenodo.18337360
Primary Topic
Oral microbiology and periodontitis research
Type
article
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article

Conceptual Insight on Maintaining Oral- Brain axis Through Ayurveda Intervention

Prof. Dr. Jaykar Srinivasan, Dr. D. Amirtha Kadesh Abiram
Zenodo (CERN European Organization for Nuclear Research)
Oral microbiology and periodontitis research
article

Conceptual Insight on Maintaining Oral- Brain axis Through Ayurveda Intervention

Prof. Dr. Jaykar Srinivasan, Dr. D. Amirtha Kadesh Abiram
article en

Abstract

Introduction: Oral health and cognitive health are intricately connected. The health of our teeth, gums, and oral cavity have a direct influence on the health of our brain. The brain and oral connection are quite profound emerging evidence suggests a significant link between the oral microbiome and neuropsychiatric disorders, including depression Methods and Materials: A literature review was collected using databases, to examining the connection between oral microbiota and depression. So, when we have poor oral care which eventually results in mental function disabilities like anxiety and depression. Studies states that the composition of the salivary microbiome like Spirochaetaceae, Actinomyces were found to be associated with severity of depressive and anxiety symptoms in adolescents. This indicates that oral microbes can travel up into the brain. Review in classics explains about the Gandusha and Kavala procedure which concentrate more on the oral health can be linked to evaluate the efficacy in modulating oral flora and improving mental health. Results: Gandusha and Kavala is other form of drug administration into the oral cavity in which the active ingredients and chemical constituents of the drug are absorbed through the buccal mucosa and reach the blood stream. Discussion: Studies that have looked at the brain of Alzheimer’s patients during autopsies have actually found oral pathogens present in brain tissue. Gandusha and Kavala may serve as adjunctive tools in the prevention and management of depression by targeting upstream factors such as oral dysbiosis. Oral therapies not only support oral hygiene but may also reduce neuroinflammatory signals implicated in mood disorders via the oral-gut-brain axis. Conclusion: The Oral Gut Brain Axis linked with Gandusha and Kavala procedure using offer promising, low-cost preventive strategies that support microbial balance and mental wellness.

Zenodo (CERN European Organization for Nuclear Research)
Vaidyaratnam P.S. Varier Ayurveda College (IN), Desh Bhagat Ayurvedic College and Hospital (IN)
No poverty
Openalex Percentile: Top 82%
Oral microbiology and periodontitis research
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