Reduced circulating STOX1 is associated with inflammatory cytokines and insulin resistance in obese individuals: a cross-sectional study
During OGTT, hyperglycemia suppressed circulating STOX1, suggesting glucose-dependent regulation of its secretion/release. Collectively, these findings indicate that decreased serum STOX1 tracks adverse metabolic and inflammatory profiles in obesity and support its potential utility as a noninvasive biomarker of adipose tissue inflammation in overweight/obese individuals.
Authors
- Shan Geng (ORCID: https://orcid.org/0000-0003-0838-4726)
- Li Jian
- Xianmei Jiang
- Mingliang Xiang
- Mingsha Shuai
- Yanping Wang
Institutions
- Chongqing Dazu District People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fnut.2026.1734606
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00