Renal Ketogenesis Protects Against Ischemic Kidney Injury
Loss of renal HMGCS2 and resultant ketogenesis increased ischemia-induced injury and decreased mitochondrial fatty acid oxidation capacity, suggesting a role in renal ketogenesis in limiting AKI.
Authors
- Andrea H. Venable
- mina khayyat rasouli
- Kyle Feola (ORCID: https://orcid.org/0000-0002-1190-9696)
- Ricardo Monroy
- Chetana Jadhav
- Emma-Grace Haley
- Tatyana McCoy
- Sarah C. Huen
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1681/asn.0000001014
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- University of Texas Southwestern Medical Center
- Ministry of Education, India
- University of California, San Diego
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases