Outcomes following definitive treatment of malignant peripheral nerve sheath tumor are significantly worse for patients with neurofibromatosis type 1: A Canadian Sarcoma Research and Clinical Collaboration study
In summary, this study suggests that patients with NF1-associated MPNSTs experience worse outcomes. NF1 associated MPNSTs were larger and arose in locations less amenable to negative (R0) resections. Among resectable tumors, CIDM, the primary driver of survival in patients initially diagnosed with localized disease, was correlated to tumor size but not NF1 status.
Authors
- Pamela Psarianos (ORCID: https://orcid.org/0000-0001-8967-3276)
- Hagit Peretz Soroka
- Anna Santiago (ORCID: https://orcid.org/0000-0002-0932-2386)
- R. Aubrey
- David Shultz (ORCID: https://orcid.org/0000-0001-8242-6555)
- Aakar Gupta (ORCID: https://orcid.org/0000-0001-6435-3583)
- P. C. Ferguson
- Anthony M. Griffin (ORCID: https://orcid.org/0000-0003-4462-3974)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- Sinai Health System (CA)
Publication Details
- Journal
- Cancer
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/cncr.70263
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00