Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis-Associated CoughThis study evaluated whether oral nalbuphine extended release (ER) reduces cough and improves patient-reported outcomes in patients with idiopathic pulmonary fibrosis (IPF) and chronic cough. Why Does This Clinical Trial Matter?IPF is a progressive lung disease with high rates of mortality and significant impairment in quality of life.Up to 80% of patients with IPF experience chronic cough and current treatments do not effectively address this symptom.New options are needed.

Publication Details

Journal
JAMA
Published
2026-01-22
DOI
https://doi.org/10.1001/jama.2025.26285
Primary Topic
Respiratory and Cough-Related Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough

JAMA
Respiratory and Cough-Related Research
article

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough

article en

Abstract

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis-Associated CoughThis study evaluated whether oral nalbuphine extended release (ER) reduces cough and improves patient-reported outcomes in patients with idiopathic pulmonary fibrosis (IPF) and chronic cough. Why Does This Clinical Trial Matter?IPF is a progressive lung disease with high rates of mortality and significant impairment in quality of life.Up to 80% of patients with IPF experience chronic cough and current treatments do not effectively address this symptom.New options are needed.

JAMAVol. 335(12)
Zero hunger
Openalex Percentile: Top 82%
Respiratory and Cough-Related Research
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Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough · JAMA (2026) | TGRS Research Map | TGRS