Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease
This study shows that fibrosis activity measured by PRO-C3 captures dynamic disease processes in alcohol-related liver disease that are not fully reflected by histological fibrosis stage. These findings are important for clinicians and patients because PRO-C3 independently predicts decompensation and supports stratifying risk by fibrosis activity in addition to stage. Practically, incorporating fibrosis-activity biomarkers could guide earlier monitoring and interventions aimed at modulating fibrogenic activity.
Authors
- Katrine Holtz Thorhauge (ORCID: https://orcid.org/0000-0003-0411-0373)
- K. Bech (ORCID: https://orcid.org/0000-0002-3760-0689)
- Ida Falk Villesen (ORCID: https://orcid.org/0000-0001-7921-9707)
- Stine Johansen (ORCID: https://orcid.org/0000-0002-5031-2294)
- M Karsdal
- Helle Lindholm Schnefeld (ORCID: https://orcid.org/0009-0009-6566-9681)
- Mads Israelsen
- Peter Andersen
- Johanne Kragh Hansen
- Camilla Dalby Hansen
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Nordic Bioscience (Denmark) (DK)
Publication Details
- Journal
- JHEP Reports
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.jhepr.2026.101746
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Novo Nordisk
- Odense Universitetshospital
- Syddansk Universitet
- Novo Nordisk Fonden
- Norgine