Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis

Combined treatment outperforms pharmacotherapy alone regardless of individual characteristics. Thus, its delivery does not have to be limited to specific patient subgroups. However, IPD were available for only 41% of eligible studies, thus limiting this sample's representativeness.

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Publication Details

Journal
Psychotherapy and Psychosomatics
Published
2026-01-21
DOI
https://doi.org/10.1159/000550633
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00

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article

Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis

Andrea K. Wittenborn, Giuseppe Maina, Robert J. DeRubeis, Y. Burnand et al.
Psychotherapy and Psychosomatics
Treatment of Major Depression
article

Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis

Andrea K. Wittenborn, Giuseppe Maina, Robert J. DeRubeis, Y. Burnand, Lisa Wallner Samstag, Markéta Čihařová, Frank Röhricht, Nusrat Husain, Han Choi, Joel M. Town, Ingo Zobel, Lingyao Tong, David J. Hellerstein, Ellen Driessen, Arpana Amarnath, Curt Hemanny, Nicola Wiles, ángela Palao, J Milgrom, Steven D. Hollon, Blom Mb, Claudia Buntrock, Jaime López Rodríguez, Antonio Andreoli, Sreevani Rentala, Clara Miguel, Mathias Harrer, Livia Hartmann de Souza, Martin B. Keller, Pim Cuijpers, Kevin L. Delucchi, Gianluca Rosso, Ying Chen, Heleen Riper, Erica Weitz, Raymond W. Lam, Elisabeth Schramm, Irismar Reis de Oliveira, Toshi A. Furukawa, David J. A. Dozois, Beatriz Rodríguez Vega, Valerio Villamil Salcedo, Eirini Karyotaki, Atsuo Nakagawa, Arun Ravindran, Charles F. Reynolds III, Jack Dekker, Constantin Yves Plessen, François Lespérance, Brandon A. Gaudiano
article en

Abstract

Combined treatment outperforms pharmacotherapy alone regardless of individual characteristics. Thus, its delivery does not have to be limited to specific patient subgroups. However, IPD were available for only 41% of eligible studies, thus limiting this sample's representativeness.

Psychotherapy and Psychosomatics
United Nations Institute for Training and Research (CH), Western University (CA), Universidade Federal da Bahia (BR), Dalhousie University (CA), Universidade Federal do Rio Grande do Sul (BR), Long Island University (US), University of British Columbia (CA), Radboud University Nijmegen (NL), University of Freiburg (DE), St. Marianna University School of Medicine (JP), The University of Melbourne (AU), University of Pittsburgh (US), University of California, San Francisco (US), University of Toronto (CA), Vanderbilt University (US), Medical University of Graz (AT), Kyoto University (JP), Brown University (US), Hospital Universitario La Paz (ES), East London NHS Foundation Trust (GB), Butler Hospital (US), University of Manchester (GB), Babeș-Bolyai University (RO), New York Psychoanalytic Society and Institute (US), University of Bristol (GB), Parnassia Groep (NL), Institute of Mental Health (IN), Hospital de Clínicas de Porto Alegre (BR), University Hospital of Geneva (CH), Mersey Care NHS Trust (GB), Instituto de Saúde (BR), Hochschule Fresenius (DE), GGD Amsterdam (NL), Indian Institute of Technology Dharwad (IN), Ospedale San Luigi Gonzaga (IT), Pro Persona (NL), Austin Health (AU), Institute of Mental Health and Neurosciences, New York State Psychiatric Institute, Sun Moon University (KR), University of Turin (IT), Technical University of Munich (DE), Universidad Autónoma de Madrid (ES), Université de Montréal (CA), Columbia University (US), University of Pennsylvania (US), Vrije Universiteit Amsterdam (NL), Michigan State University (US), University of Amsterdam (NL), Otto-von-Guericke-Universität Magdeburg (DE)
National Institute for Health and Care Research, Department of Health and Social Care, Manchester Biomedical Research Centre, National Institute of Mental Health
Good health and well-being
Openalex Percentile: Top 79%
Treatment of Major Depression
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