Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis
Combined treatment outperforms pharmacotherapy alone regardless of individual characteristics. Thus, its delivery does not have to be limited to specific patient subgroups. However, IPD were available for only 41% of eligible studies, thus limiting this sample's representativeness.
Authors
- Andrea K. Wittenborn (ORCID: https://orcid.org/0000-0003-4608-0635)
- Giuseppe Maina (ORCID: https://orcid.org/0000-0002-2533-140X)
- Robert J. DeRubeis (ORCID: https://orcid.org/0000-0003-3129-0277)
- Y. Burnand
- Lisa Wallner Samstag (ORCID: https://orcid.org/0000-0002-4899-5241)
- Markéta Čihařová (ORCID: https://orcid.org/0000-0002-7131-1549)
- Frank Röhricht (ORCID: https://orcid.org/0000-0001-7487-7970)
- Nusrat Husain
- Han Choi (ORCID: https://orcid.org/0000-0003-0406-5605)
- Joel M. Town (ORCID: https://orcid.org/0000-0003-0587-1035)
- Ingo Zobel (ORCID: https://orcid.org/0000-0001-9372-585X)
- Lingyao Tong (ORCID: https://orcid.org/0000-0002-5023-6949)
- David J. Hellerstein (ORCID: https://orcid.org/0000-0002-8031-4354)
- Ellen Driessen (ORCID: https://orcid.org/0000-0002-9602-1548)
- Arpana Amarnath (ORCID: https://orcid.org/0000-0002-8966-4668)
- Curt Hemanny (ORCID: https://orcid.org/0000-0002-9698-2517)
- Nicola Wiles (ORCID: https://orcid.org/0000-0002-5250-3553)
- ángela Palao
- J Milgrom
- Steven D. Hollon (ORCID: https://orcid.org/0000-0001-5005-3862)
- Blom Mb
- Claudia Buntrock (ORCID: https://orcid.org/0000-0002-4974-5455)
- Jaime López Rodríguez
- Antonio Andreoli
- Sreevani Rentala
- Clara Miguel
- Mathias Harrer
- Livia Hartmann de Souza
- Martin B. Keller
- Pim Cuijpers
- Kevin L. Delucchi
- Gianluca Rosso
- Ying Chen
- Heleen Riper
- Erica Weitz
- Raymond W. Lam
- Elisabeth Schramm
- Irismar Reis de Oliveira
- Toshi A. Furukawa
- David J. A. Dozois
- Beatriz Rodríguez Vega
- Valerio Villamil Salcedo
- Eirini Karyotaki
- Atsuo Nakagawa
- Arun Ravindran
- Charles F. Reynolds III
- Jack Dekker
- Constantin Yves Plessen
- François Lespérance
- Brandon A. Gaudiano
Institutions
- United Nations Institute for Training and Research (CH)
- Western University (CA)
- Universidade Federal da Bahia (BR)
- Dalhousie University (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- Long Island University (US)
- University of British Columbia (CA)
- Radboud University Nijmegen (NL)
- University of Freiburg (DE)
- St. Marianna University School of Medicine (JP)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- Medical University of Graz (AT)
- Kyoto University (JP)
- Brown University (US)
- Hospital Universitario La Paz (ES)
- East London NHS Foundation Trust (GB)
- Butler Hospital (US)
- University of Manchester (GB)
- Babeș-Bolyai University (RO)
- New York Psychoanalytic Society and Institute (US)
- University of Bristol (GB)
- Parnassia Groep (NL)
- Institute of Mental Health (IN)
- Hospital de Clínicas de Porto Alegre (BR)
- University Hospital of Geneva (CH)
- Mersey Care NHS Trust (GB)
- Instituto de Saúde (BR)
- Hochschule Fresenius (DE)
- GGD Amsterdam (NL)
- Indian Institute of Technology Dharwad (IN)
- Ospedale San Luigi Gonzaga (IT)
- Pro Persona (NL)
- Austin Health (AU)
- Institute of Mental Health and Neurosciences
- New York State Psychiatric Institute
- Sun Moon University (KR)
- University of Turin (IT)
- Technical University of Munich (DE)
- Universidad Autónoma de Madrid (ES)
- Université de Montréal (CA)
- Columbia University (US)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
- Michigan State University (US)
- University of Amsterdam (NL)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Psychotherapy and Psychosomatics
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1159/000550633
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Manchester Biomedical Research Centre
- National Institute of Mental Health