Urokinase Plasminogen Activator Deficiency Delays the Development of Obesity and Metabolic Sequelae
Our findings suggest that global uPA deletion, but not selective deletion of uPA in LysM+ myeloid cells, attenuates the development of early-stage HFD-driven obesity and pathologies consistent with metabolic syndrome.
Authors
- Oscar Negrón (ORCID: https://orcid.org/0000-0002-5234-8397)
- Zimu Wei
- Angelica T. Jameson
- Else-Marie Bladbjerg
- Woosuk S. Hur
- James P. Luyendyk
- Haley E. Hanes
- Yesha N. Patel
- Nadja B. Pedersen
- Matthew J. Flick
- Mario S.Y. Giacomazzo
- Alisa S. Wolberg
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Southern Denmark (DK)
- Anna Needs Neuroblastoma Answers (US)
- Hospital South West Jutland (DK)
- Michigan State University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/atvbaha.125.324017
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 24.82