Unraveling the mechanism of mulberry leaf in alleviating hyperuricemia: key role of kaempferol by modulating AKT pathway and gut-kidney axis
Kaempferol may regulate UA metabolism and inflammatory injury by modulating the AKT signaling pathway, and exert its effects on the gut-kidney axis and restoring gut microbiota composition.
Authors
- Zixuan Guo (ORCID: https://orcid.org/0009-0009-5893-0941)
- Zilong Wang (ORCID: https://orcid.org/0009-0000-9462-8330)
- Boyi Zhang (ORCID: https://orcid.org/0000-0001-8418-2275)
- Junhong Huang (ORCID: https://orcid.org/0000-0003-2997-2201)
- Qianqian Wang
- Shuying Feng
- Yuanyuan Niu
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fmicb.2026.1752775
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Henan Province