Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches

These strategies represent a paradigm shift toward precision medicine, but challenges like toxicity and biomarker-driven resistance persist. Future directions include AI-guided predictions and novel degraders like proteolysis-targeting chimeras (PROTACs).

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-22
DOI
https://doi.org/10.3389/fphar.2025.1742651
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches

J Q Chen, Qianyu Han, Shasha Jiang, Lei Xue
Frontiers in Pharmacology
CAR-T cell therapy research
article

Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches

J Q Chen, Qianyu Han, Shasha Jiang, Lei Xue
article en

Abstract

These strategies represent a paradigm shift toward precision medicine, but challenges like toxicity and biomarker-driven resistance persist. Future directions include AI-guided predictions and novel degraders like proteolysis-targeting chimeras (PROTACs).

Frontiers in PharmacologyVol. 16
Shanghai Changzheng Hospital (CN), 82th Hospital of Pla (CN)
Good health and well-being
Openalex Percentile: Top 81%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches — J Q Chen, Qianyu Han, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS