Metabolomics profiles associated with SARS-CoV-2 -IgG serostatus as an alternative diagnostic approach
Our findings identify metabolomic alterations associated with SARS-CoV-2 infection between IgG-positive and IgG-negative individuals. The identified metabolites are involved in regulating lipid metabolism, immune response, and the inflammatory signaling pathways. The results offer preliminary hypothesis generating insights into the underlying changes that may inform future research on host-immune interactions in COVID-19. Changes in these metabolites need to be validated in larger and independent cohorts.
Authors
- Raghad AlQurashi
- Assim A. Alfadda (ORCID: https://orcid.org/0000-0002-4792-5188)
- Ahmed A. Albarraq (ORCID: https://orcid.org/0000-0003-2212-5173)
- Khaled Alabdulkareem (ORCID: https://orcid.org/0000-0002-1865-178X)
- Monera S. M. S. Alrukhayes
- Abdullah M. Asiri (ORCID: https://orcid.org/0000-0001-7905-3209)
- Hani Jokhdar (ORCID: https://orcid.org/0000-0001-5952-9580)
- Ahdab Alsaieedi
- Afshan Masood (ORCID: https://orcid.org/0000-0001-8082-9326)
- Esraa A. Hawsa
- Mariam M Al Eissa
- Reem Almalki
- Randh AlAhmari
- Muath ben shaded
- Khalid H. AlAnazi
- Anas Abdel Rahman
- Sami S. Almudrra
- Yousef Mall
Institutions
- Alfaisal University (SA)
- King Abdulaziz University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
- King Saud University (SA)
- King Abdulaziz Medical City (SA)
- Saudi Arabian Monetary Authority (SA)
- Kuwait University (KW)
- Saudi Center for Disease Prevention and Control (SA)
- Ministry of Health (SA)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.jiph.2026.103155
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00