Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art
Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed is the so-called “Hi-C” chromatin interaction map with its distinct checker-board patterns which when combined with simulations have revealed the complex structure of the folded genome. Here, we describe an art-science collaboration which arose through combining local and global inter-personal connections, and which illustrates the equivalent short- and long-range contacts within folded genomes.
Authors
- Caroline A. Austin (ORCID: https://orcid.org/0000-0002-1921-5947)
- Sarah Anne Harris (ORCID: https://orcid.org/0000-0002-2812-1651)
- Mary Griffiths
- Job Dekker
Institutions
- Howard Hughes Medical Institute (US)
- University of Massachusetts Chan Medical School (US)
- Leeds Arts University (GB)
- Massachusetts Institute of Technology (US)
- Newcastle University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Biophysics Reviews
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1063/5.0283280
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Leeds
- National Institutes of Health
- Engineering and Physical Sciences Research Council