Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art

Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed is the so-called “Hi-C” chromatin interaction map with its distinct checker-board patterns which when combined with simulations have revealed the complex structure of the folded genome. Here, we describe an art-science collaboration which arose through combining local and global inter-personal connections, and which illustrates the equivalent short- and long-range contacts within folded genomes.

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Publication Details

Journal
Biophysics Reviews
Published
2026-01-22
DOI
https://doi.org/10.1063/5.0283280
Primary Topic
Genomics and Chromatin Dynamics
Type
article
Field-Weighted Citation Impact
0.00

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article

Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art

Caroline A. Austin, Sarah Anne Harris, Mary Griffiths, Job Dekker
Biophysics Reviews
Genomics and Chromatin Dynamics
article

Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art

Caroline A. Austin, Sarah Anne Harris, Mary Griffiths, Job Dekker
article en

Abstract

Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed is the so-called “Hi-C” chromatin interaction map with its distinct checker-board patterns which when combined with simulations have revealed the complex structure of the folded genome. Here, we describe an art-science collaboration which arose through combining local and global inter-personal connections, and which illustrates the equivalent short- and long-range contacts within folded genomes.

Biophysics ReviewsVol. 7(1)
Howard Hughes Medical Institute (US), University of Massachusetts Chan Medical School (US), Leeds Arts University (GB), Massachusetts Institute of Technology (US), Newcastle University (GB), University of Sheffield (GB)
University of Leeds, National Institutes of Health, Engineering and Physical Sciences Research Council
Openalex Percentile: Top 82%
Genomics and Chromatin Dynamics
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Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art — Caroline A. Austin, Sarah Anne Harris, et al. · Biophysics Reviews (2026) | TGRS Research Map | TGRS