DDX21 Links <i> BRAF <sup>V600E</sup> </i> and TERT to Promote Thyroid Cancer Progression
<i>BRAF<sup>V600E</sup></i> upregulates expression of DDX21 through the MEK/ERK/GABP axis. DDX21, in turn, interacts with TERT to promote rRNA transcription and modulate the expression of multiple cancer hallmark genes, driving the malignant progression of thyroid cancer. These findings suggest that DDX21 acts as a mediator to bridge the crosstalk between <i>BRAF<sup>V600E</sup></i> and TERT and may serve as a therapeutic target for patients with thyroid cancer harboring <i>BRAF</i> and <i>TERT</i> alterations.
Authors
- Shubin Hong
- Ye Sang
- Q. Zhang
- Shaojun Yu
- Xi Xiao (ORCID: https://orcid.org/0000-0002-6622-503X)
- Lefan Zhu
- Haipeng Xiao
- Guanghui Hu (ORCID: https://orcid.org/0000-0002-5089-4052)
- Ke Jiang
- Rengyun Liu
- Weiming Lv
- Mengke Chen
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Thyroid
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1177/10507256261417697
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00