Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction
This is the first study to identify transcriptional regulators that drive endothelial CB1 upregulation in response to disturbed flow. We further demonstrated that isoflavone monophosphates ameliorate disturbed flow-induced endothelial dysfunction and EndMT via CB1 inhibition, offering promising oral therapeutics for atherosclerosis.
Authors
- Hsin-Ya Tsai (ORCID: https://orcid.org/0000-0001-9769-0914)
- Dai-Jung Chung
- Nan‐Wei Su (ORCID: https://orcid.org/0000-0002-1402-7349)
- Wu Cho-Kai
- Chia-Yu Liu (ORCID: https://orcid.org/0000-0003-1823-190X)
- Ming-Tao Zhao
- Kai-Chien Yang
- Sheng-Wei Lin
- Wei-Hsuan Liu
- Tzu-Tang Wei
- Shao-Peng Chen
- Chen Hsu
- Jiun‑Jie Shie
Institutions
- Nationwide Children's Hospital (US)
- National Taiwan University (TW)
- Institute of Biological Chemistry, Academia Sinica (TW)
- National Taiwan University Hospital (TW)
- Institute of Molecular Biology, Academia Sinica (TW)
- Institute of Chemistry, Academia Sinica (TW)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1186/s12929-026-01214-5
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University
- National Science and Technology Council