Beyond traditional—the sick cirrhosis patient scores integrating cytokine and immune profiling for precision prognosis in hospitalized cirrhosis patients may help predict infection, ICU admission and long-term death post hospitalization
Biomarkers reflecting systemic inflammation (IL-6, procalcitonin), immune paresis (low nucleated cell count), and failed regenerative capacity (low EGF) strongly predicted adverse outcomes. Integrating these markers into the proposed 'Sick Cirrhosis Patient Scores' may improve risk stratification, but these models require rigorous external validation.
Authors
- Ajit K. Tharakan (ORCID: https://orcid.org/0000-0002-6430-2580)
- Tharun Tom Oommen (ORCID: https://orcid.org/0000-0003-0511-5002)
- Sunitha Thomas
- A. Grace Baby (ORCID: https://orcid.org/0009-0006-1469-9934)
- Sunitha Mary John
- Arif Hussain Theruvath (ORCID: https://orcid.org/0000-0002-3570-3465)
- Ansu Abu Alex
- Philip Augustine (ORCID: https://orcid.org/0000-0003-0787-0984)
- Cyriac Abby Philips (ORCID: https://orcid.org/0000-0002-9587-336X)
- Aryalakshmi Sreemohan (ORCID: https://orcid.org/0009-0004-6960-4627)
- Rizwan Ahamed
Institutions
- Rajagiri Hospital (IN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fmed.2026.1736956
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00