Role of purinergic receptors 2X3 on type II spiral ganglion neurons in the enhancement of medial olivocochlear reflex in mice after long-term noise exposure
The enhanced MOC reflex induced by long-term moderate noise exposure is mediated by the upregulation of P2X3 receptors on type II SGNs. The selective ablation of type I SGNs confirms the pivotal role of type II SGNs in this adaptive neural plasticity.
Authors
- Peidong Dai
- Na Shen (ORCID: https://orcid.org/0000-0003-1557-1060)
- Yapeng Li (ORCID: https://orcid.org/0009-0005-0224-3596)
- Xinsheng Huang (ORCID: https://orcid.org/0000-0003-1106-0917)
- Dongming Yin
Institutions
- Fudan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1097/wnr.0000000000002224
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00