Molecular Imaging of Collagen Turnover in Myocardial Infarction
<sup>99m</sup>Tc-(HE)<sub>3</sub>-(GPO)<sub>9</sub> enables non-invasive detection of denatured collagen as a marker of collagen remodeling in vivo, offering a promising tool for assessing fibrotic remodeling after MI. Collagen, procollagen, and denatured collagen, along with MMP activation, exhibit distinct patterns, and their combined imaging may provide a comprehensive molecular fingerprint of cardiac fibrosis, advancing personalized management of cardiomyopathy.
Authors
- Mani Salarian
- Onur Varli
- Afarin Neishabouri
- Mean Ghim (ORCID: https://orcid.org/0000-0002-0723-3662)
- Azmi A. Ahmad (ORCID: https://orcid.org/0000-0003-0326-440X)
- Jakub Toczek (ORCID: https://orcid.org/0000-0003-0639-8075)
- ZhengXing Zhang (ORCID: https://orcid.org/0009-0003-6448-338X)
- Fadi G. Akar (ORCID: https://orcid.org/0000-0001-9146-8407)
- Gunjan Kukreja (ORCID: https://orcid.org/0000-0002-1913-7387)
- Jiasheng Zhang (ORCID: https://orcid.org/0000-0001-6097-1384)
- Jie Li (ORCID: https://orcid.org/0000-0002-2335-582X)
- Mehran M Sadeghi
- Daniel Ein Alshaeba
- S. Michael Yu
- Chi Liu
Institutions
- University of Utah (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-20
- DOI
- https://doi.org/10.64898/2026.01.16.699986
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00