Septic shock reduces intestinal microcirculation and anastomotic perfusion: A porcine laser speckle contrast imaging study
This study shows that septic shock significantly impairs intestinal microcirculation indicating a risk of intestinal ischemia if bacteriaemia and subsequent septic shock is untreated. Due to diminish blood flow following septic shock, the anastomotic healing may be compromised leading to increased risk of anastomotic leakage. Conclusively, this study provides a foundation for optimizing surgical strategies and improving patient outcomes in this high-risk population.
Authors
- Rupan Paramasivam
- Nickolai Malte Kristensen (ORCID: https://orcid.org/0000-0002-5570-4836)
- Anders Husted Madsen (ORCID: https://orcid.org/0000-0003-1792-8676)
- Helen Woldeselassie
- Louise Kruse Jensen
- Susie Sarah Paramasivam
- Mai-Britt Worm Ørntoft
- Claudia Jaensch
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Regionshospitalet Herning (DK)
- Regional Hospital West Jutland (DK)
Publication Details
- Journal
- World Journal of Gastrointestinal Surgery
- Published
- 2026-01-21
- DOI
- https://doi.org/10.4240/wjgs.v18.i1.111928
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00