Extracellular Vesicles in Gingival Crevicular Fluid as Indicators of Periodontitis and Early Response to Non‐surgical Periodontal Therapy
Our study aims to profile EV subtypes and cytokines (IL-4, IL-10, IL-1β, TNF-α) across (1) shallow pockets (≤ 3 mm) in healthy, gingivitis, and periodontitis patients, and (2) deep pockets (≥ 6 mm) in periodontitis patients before and 1 month after NSPT. Preliminary data suggest that sEV-IL-4 and CD9<sup>+</sup> sEV may reflect treatment response in periodontitis, being elevated in responding versus nonresponding sites.
Authors
- Peisong Han
- Sašo Ivanovski (ORCID: https://orcid.org/0000-0001-5339-0936)
- Carlos F. Salomon
- Andrew Liaw
- Akila Suboda Vithanage
Institutions
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1111/jre.70070
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Queensland
- Australian Dental Research Foundation
- Metro North Hospital and Health Service