Chronic sleep loss and A1 adenosine receptors in the human brain
The results indicate that chronic sleep loss likely induces parallel upregulations of extracellular adenosine and A1AR resulting in no net gain in receptor availability. The results contrast with findings from acute sleep deprivation in which we found impaired performance and increased A1AR availability that were restored to rested levels after recovery sleep. The findings reveal fundamental differences in the mechanisms through which acute and chronic sleep loss affect adenosinergic regulation and cognitive performance.
Authors
- Denise Lange (ORCID: https://orcid.org/0000-0002-0853-1987)
- Simone Beer (ORCID: https://orcid.org/0000-0003-4290-4051)
- Katharina Thiel (ORCID: https://orcid.org/0000-0001-8297-1094)
- David Elmenhorst (ORCID: https://orcid.org/0000-0001-6137-416X)
- Eva Hennecke (ORCID: https://orcid.org/0000-0002-7717-8937)
- Daniel Aeschbach (ORCID: https://orcid.org/0000-0002-6054-5753)
- Bernd Neumaier
- Eva-Maria Elmenhorst
- Andreas Bauer
Institutions
- University of Bonn (DE)
- Forschungszentrum Jülich (DE)
- University of Münster (DE)
- University Hospital Bonn (DE)
- Human Factors (Norway) (NO)
- University Hospital Cologne (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- SLEEP
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1093/sleep/zsag012
- Primary Topic
- Sleep and Work-Related Fatigue
- Type
- article
- Field-Weighted Citation Impact
- 0.00