MHC one–two punch knocks out cancer

In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20250025) describe complete T cell antigens (CTAs), comprised of class I and class II immunogenic peptides fused in a single polypeptide that greatly increase the effectiveness of cancer immunotherapy, even when the CTA antigens are not expressed in tumor cells.

Authors

Yewdell Jw
Amir Ghorbani

Institutions

National Institute of Allergy and Infectious Diseases (US)

Publication Details

Journal: The Journal of Experimental Medicine
Published: 2026-01-06
DOI: https://doi.org/10.1084/jem.20252203
Primary Topic: Immunotherapy and Immune Responses
Type: article
Field-Weighted Citation Impact: 0.00

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article

MHC one–two punch knocks out cancer

Yewdell Jw, Amir Ghorbani

Jan 6, 2026

The Journal of Experimental Medicine

Immunotherapy and Immune Responses

article

MHC one–two punch knocks out cancer

Yewdell Jw, Amir Ghorbani

January 6, 2026article en

Abstract

The Journal of Experimental MedicineVol. 223(2)

National Institute of Allergy and Infectious Diseases (US)

Good health and well-being

Openalex Percentile: Top 82%

Immunotherapy and Immune Responses

DOI Source OpenAlex

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MHC one–two punch knocks out cancer — Yewdell Jw, Amir Ghorbani · The Journal of Experimental Medicine (2026) | TGRS Research Map | TGRS