Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy

In this systematic review and meta-analysis of controlled clinical trials investigating PAT for depressive symptoms, a greater quantity of preparation therapy was associated with significantly larger reductions of depressive symptoms. These findings highlight a potential key role of preparation in optimizing PAT outcomes. The observed association primarily reflects quantitative aspects of therapy exposure rather than qualitative or process-related dimensions of the therapeutic interaction. Additional systematic research is needed to clarify this association and optimize all therapeutic components within psychedelic interventions.