Esophagectomy vs Active Surveillance in Clinical Complete Responders After Neoadjuvant Chemoradiation

This study found that while active surveillance offers short-term quality-of-life benefits and may be appropriate in select patients, particularly those at low recurrence risk or with high surgical risk, esophagectomy remains the preferred strategy for maximizing long-term survival and QALYs. These findings support a nuanced, individualized approach to post-nCRT management, balancing organ preservation with long-term oncologic outcomes.

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Publication Details

Journal
JAMA Surgery
Published
2026-01-21
DOI
https://doi.org/10.1001/jamasurg.2025.5890
Primary Topic
Esophageal Cancer Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Esophagectomy vs Active Surveillance in Clinical Complete Responders After Neoadjuvant Chemoradiation

Tiago Ribeiro, Steven Hsesheng Lin, Julie Hallet, Natalie G. Coburn et al.
JAMA Surgery
Esophageal Cancer Research and Treatment
article

Esophagectomy vs Active Surveillance in Clinical Complete Responders After Neoadjuvant Chemoradiation

Tiago Ribeiro, Steven Hsesheng Lin, Julie Hallet, Natalie G. Coburn, Michael Ko, Vaibhav Gupta, Adom Bondzi-Simpson, Biniam Kidane
article en

Abstract

This study found that while active surveillance offers short-term quality-of-life benefits and may be appropriate in select patients, particularly those at low recurrence risk or with high surgical risk, esophagectomy remains the preferred strategy for maximizing long-term survival and QALYs. These findings support a nuanced, individualized approach to post-nCRT management, balancing organ preservation with long-term oncologic outcomes.

JAMA SurgeryVol. 161(3)
Sunnybrook Health Science Centre (CA), Mayo Clinic (US), The University of Texas MD Anderson Cancer Center (US), University of Toronto (CA), London Health Sciences Centre (CA), Health Sciences Centre (CA), University of Manitoba (CA)
Openalex Percentile: Top 82%
Esophageal Cancer Research and Treatment
DOIOpen Access PDFOpenAlex
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