Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis
Leukemia exosomes suppress DC function primarily through MRPL58-associated metabolic modulation and TNF-β signaling. MRPL58 represents a promising therapeutic target. Disrupting exosome-mediated immunosuppression could enhance DC-based vaccines and combination immunotherapies for leukemia.
Authors
- Hongxia Chen (ORCID: https://orcid.org/0000-0003-1415-0950)
- Wei Luo (ORCID: https://orcid.org/0000-0002-4711-7543)
- Hui Zhong (ORCID: https://orcid.org/0000-0002-1933-3046)
- Xiaohong Xie (ORCID: https://orcid.org/0000-0002-3426-4253)
- Rui Huang
- Yangjun Liu
- Yang Tao
- Jinglong Lv
- Zhudan Hou
Institutions
- Chongqing University (CN)
- Third Way (US)
Publication Details
- Journal
- Hematology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1080/16078454.2026.2616554
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00