Oral indole‐3‐propionic acid preserves β‐cell function and improves glucose homeostasis in diabetic mice via <scp>FOXA1</scp> – <scp>SGPP1</scp> – <scp>HSPA5</scp> signalling
IPA protects pancreatic β-cells by activating the FOXA1-SGPP1-HSPA5 signalling pathway, thereby alleviating ER stress and enhancing β-cell survival.
Authors
- Fangyi Zhu
- X. Zhang
- X. Liu
- Jinjian A. Pan
- Zixiao Liang
- Yifan Ma (ORCID: https://orcid.org/0000-0001-6962-8582)
- Huanyu Wu
- Chunxun Liu
- Mengjie Xiao
- Leyao Qi
- Changhao Sun
Institutions
- Harbin Medical University (CN)
- Ministry of Education (SA)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1111/dom.70471
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00