KLF11 interacts with MDM2 to stabilize E2F1 and promotes DNA damage repair to induce radioresistance in esophageal cancer cells
This study elucidates the critical role and molecular mechanism through which KLF11 drives radiotherapy resistance in ESCC by regulating the MDM2/E2F1 axis and enhancing HR repair, thereby providing a solid theoretical foundation and potential target for the development of KLF11-targeted radiosensitization therapies for ESCC.
Authors
- Dongmei Zhao (ORCID: https://orcid.org/0000-0001-5156-6125)
- Man S. Li
- Songqin Li
- Jiazhu Wang
- Yaoxiong Xia
- Yanli Li
- Renyi Dong
- Li Wang
Institutions
- Kunming Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Baoshan University (CN)
Publication Details
- Journal
- Pathology - Research and Practice
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.prp.2026.156375
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00