Inhibition of Pseudomonas aeruginosa Biofilm Formation by Peptidyl-Arginine Deiminases 2 and 4
These results demonstrate that PADs inhibit P. aeruginosa biofilm formation and decrease the production of QS-related virulence factors, highlighting their potential as novel antimicrobials and supporting further research into the development of PAD-based therapeutics.
Authors
- Luke Forde (ORCID: https://orcid.org/0000-0002-3738-6512)
- Rory Baird (ORCID: https://orcid.org/0000-0003-4242-0954)
- Brenton Cavanagh (ORCID: https://orcid.org/0000-0002-1582-5756)
- Debananda Gogoi (ORCID: https://orcid.org/0000-0003-3108-8001)
- Emer P. Reeves (ORCID: https://orcid.org/0000-0002-1922-0447)
- Mengxin Niu
- Sara Waqas Ahmed
- Fidelma Fitzpatrick
Institutions
- Royal College of Surgeons in Ireland (IE)
- Beaumont Hospital (IE)
- Molecular Medicine Ireland (IE)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1159/000550256
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00