Liver fibrosis in biliary atresia: identification of the key gene EDIL3 via integrated bioinformatics
Discoidin I-like domain 3 is a novel gene with a potentially key role in BA-related liver fibrosis, possibly influencing the proliferation and apoptosis of cholangiocytes by regulating the PI3K-AKT signaling pathway, thereby participating in the occurrence and development of liver fibrosis. This study provides new insights into the molecular mechanisms and potential treatment strategies for BA.
Authors
- Shisong Zhang
- Meng Kong (ORCID: https://orcid.org/0000-0002-7879-8839)
- Jinhua Jia
- Hongzhen Liu
- Chuanyang Liu
Institutions
- Jinan Maternity And Care Hospital (CN)
- Shandong Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fmed.2025.1726141
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province