Liver fibrosis in biliary atresia: identification of the key gene EDIL3 via integrated bioinformatics

Discoidin I-like domain 3 is a novel gene with a potentially key role in BA-related liver fibrosis, possibly influencing the proliferation and apoptosis of cholangiocytes by regulating the PI3K-AKT signaling pathway, thereby participating in the occurrence and development of liver fibrosis. This study provides new insights into the molecular mechanisms and potential treatment strategies for BA.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-21
DOI
https://doi.org/10.3389/fmed.2025.1726141
Primary Topic
Pediatric Hepatobiliary Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Liver fibrosis in biliary atresia: identification of the key gene EDIL3 via integrated bioinformatics

Shisong Zhang, Meng Kong, Jinhua Jia, Hongzhen Liu et al.
Frontiers in Medicine
Pediatric Hepatobiliary Diseases and Treatments
article

Liver fibrosis in biliary atresia: identification of the key gene EDIL3 via integrated bioinformatics

Shisong Zhang, Meng Kong, Jinhua Jia, Hongzhen Liu, Chuanyang Liu
article en

Abstract

Discoidin I-like domain 3 is a novel gene with a potentially key role in BA-related liver fibrosis, possibly influencing the proliferation and apoptosis of cholangiocytes by regulating the PI3K-AKT signaling pathway, thereby participating in the occurrence and development of liver fibrosis. This study provides new insights into the molecular mechanisms and potential treatment strategies for BA.

Frontiers in MedicineVol. 12
Jinan Maternity And Care Hospital (CN), Shandong Provincial Hospital (CN)
Natural Science Foundation of Shandong Province
Openalex Percentile: Top 82%
Pediatric Hepatobiliary Diseases and Treatments
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