Interplay of Post-Pancreatectomy Acute Pancreatitis, Postoperative Pancreatic Fistula, and Mortality after Pancreatoduodenectomy: Insights from a Comprehensive Cohort Study of 1594 Patients and Development of Predictive Nomograms

PPAP is the pivotal trigger in the CR-POPF-mortality cascade after pancreatoduodenectomy. Refinements to existing fistula risk scores and incorporating PPAP into risk models will enable precise stratification. The developed high-fidelity nomograms can effectively identify patients at imminent risk of mortality, thereby facilitating rescue interventions, after external validation across diverse institutions.

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Publication Details

Journal
Journal of the American College of Surgeons
Published
2026-01-21
DOI
https://doi.org/10.1097/xcs.0000000000001783
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
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article

Interplay of Post-Pancreatectomy Acute Pancreatitis, Postoperative Pancreatic Fistula, and Mortality after Pancreatoduodenectomy: Insights from a Comprehensive Cohort Study of 1594 Patients and Development of Predictive Nomograms

Amit Chopde, Venu Menon, Manish Bhandare, Amita Sekhar Padhy et al.
Journal of the American College of Surgeons
Pancreatic and Hepatic Oncology Research
article

Interplay of Post-Pancreatectomy Acute Pancreatitis, Postoperative Pancreatic Fistula, and Mortality after Pancreatoduodenectomy: Insights from a Comprehensive Cohort Study of 1594 Patients and Development of Predictive Nomograms

Amit Chopde, Venu Menon, Manish Bhandare, Amita Sekhar Padhy, V. Chaudhari, Aamir M. Parray, Dr Kunal Nandy, Akash Pawar, Shailesh V Shrikhande
article en

Abstract

PPAP is the pivotal trigger in the CR-POPF-mortality cascade after pancreatoduodenectomy. Refinements to existing fistula risk scores and incorporating PPAP into risk models will enable precise stratification. The developed high-fidelity nomograms can effectively identify patients at imminent risk of mortality, thereby facilitating rescue interventions, after external validation across diverse institutions.

Journal of the American College of Surgeons
Homi Bhabha National Institute (IN), Tata Memorial Hospital (IN), Apollo Gleneagles Hospitals (IN), Gleneagles Hospital (SG), Cancer Hospital and Research Institute (IN), Baby Memorial Hospital (IN), Advanced Centre for Treatment, Research and Education in Cancer (IN)
Good health and well-being
Openalex Percentile: Top 81%
Pancreatic and Hepatic Oncology Research
DOISourceOpenAlex
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Interplay of Post-Pancreatectomy Acute Pancreatitis, Postoperative Pancreatic Fistula, and Mortality after Pancreatoduodenectomy: Insights from a Comprehensive Cohort Study of 1594 Patients and Development of Predictive Nomograms — Amit Chopde, Venu Menon, et al. · Journal of the American College of Surgeons (2026) | TGRS Research Map | TGRS