Non‐Traumatic Subglottic Stenosis in Adults: Changing the Course of Disease

Key Points Non‐traumatic subglottic stenosis (NT SGS) most commonly presents as idiopathic disease (69%), with smaller proportions associated with granulomatosis with polyangiitis (22%) and ANCA‐negative vasculitis (6%). Patients with idiopathic disease required more frequent airway procedures (1.35 per year) than GPA patients on immunosuppressive therapy (0.6 per year). In idiopathic cases treated with immunosuppression, procedure rates decreased dramatically from 3.15 to 0.37 per year, while intervention intervals lengthened significantly. Among ANA‐negative SGS patients, most required no further procedures after immunosuppressive therapy, and all showed clinical improvement. These findings demonstrate that immunosuppressive therapy can effectively reduce disease burden across NT SGS subtypes, even in patients without systemic autoimmune markers.