Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells

Deletion of Tie2 alone or together with Tie1 increases the proliferation and sprouting of cardiac, but not renal or pulmonary ECs, without to neovessel formation in the heart.

Authors

Madeleine H. Lackman (ORCID: https://orcid.org/0000-0001-7016-4260)
Kari K. Alitalo (ORCID: https://orcid.org/0000-0002-7331-0902)
Sinem Karaman (ORCID: https://orcid.org/0000-0002-0719-1773)
HG Augustin
Eero Mervaala
Andrey Anisimov

Institutions

University of Helsinki (FI)
German Cancer Research Center (DE)
Heidelberg University (DE)
University Hospital Heidelberg (DE)
Wihuri Research Institute (FI)

Publication Details

Journal: Angiogenesis
Published: 2026-01-21
DOI: https://doi.org/10.1007/s10456-025-10028-2
Primary Topic: Angiogenesis and VEGF in Cancer
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Helsingin Yliopisto
Biocenter Finland
Helsinki Institute of Life Science, Helsingin Yliopisto

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells

Madeleine H. Lackman, Kari K. Alitalo, Sinem Karaman, HG Augustin et al.

Jan 21, 2026

Angiogenesis

Angiogenesis and VEGF in Cancer

article

Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells

Madeleine H. Lackman, Kari K. Alitalo, Sinem Karaman, HG Augustin, Eero Mervaala, Andrey Anisimov

January 21, 2026article en

Abstract

Deletion of Tie2 alone or together with Tie1 increases the proliferation and sprouting of cardiac, but not renal or pulmonary ECs, without to neovessel formation in the heart.

AngiogenesisVol. 29(2)

University of Helsinki (FI), German Cancer Research Center (DE), Heidelberg University (DE), University Hospital Heidelberg (DE), Wihuri Research Institute (FI)

Helsingin Yliopisto, Biocenter Finland, Helsinki Institute of Life Science, Helsingin Yliopisto

Openalex Percentile: Top 82%

Angiogenesis and VEGF in Cancer

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells — Madeleine H. Lackman, Kari K. Alitalo, et al. · Angiogenesis (2026) | TGRS Research Map | TGRS