Commensal microbe-derived butyrate enhances T follicular helper cell function to boost mucosal vaccine efficacy
Our study underscores the crucial role of the gut microbiota, particularly neomycin-depleted butyrate producing taxa, in regulating PP-Tfh cell function and IgA production. Butyrate emerges as a metabolite linking microbial metabolism to Tfh differentiation and IgA class switching. Together, these findings establish a microbiota-metabolite-Tfh cell axis essential for mucosal immune homeostasis and suggest novel strategies for enhancing vaccine efficacy and protection against enteric infections. Video Abstract.
Authors
- Seohyun Byun (ORCID: https://orcid.org/0000-0001-8151-9346)
- Haena Lee (ORCID: https://orcid.org/0000-0001-5061-2564)
- Jaegyun Noh
- Hye Eun Park (ORCID: https://orcid.org/0000-0003-1048-2827)
- Minhyuk Park (ORCID: https://orcid.org/0000-0003-3466-2638)
- S. Kim (ORCID: https://orcid.org/0009-0006-2591-0846)
- Kwang Hyun (ORCID: https://orcid.org/0000-0003-3001-3067)
- Haeun Ko (ORCID: https://orcid.org/0000-0003-1026-0861)
- John Chulhoon Park (ORCID: https://orcid.org/0000-0001-5705-2862)
- Amit Sharma (ORCID: https://orcid.org/0000-0002-8109-1690)
- Chan Johng Kim (ORCID: https://orcid.org/0000-0002-7256-0205)
- Juhun Lee (ORCID: https://orcid.org/0000-0003-2749-8665)
- Changhon Lee (ORCID: https://orcid.org/0000-0002-2810-400X)
- Junghwan Park
- Seungyeon Choi
- Sin-Hyeog Im
Institutions
- Pohang University of Science and Technology (KR)
- University of Washington (US)
- Advanced Institute of Convergence Technology (KR)
- Pohang TechnoPark (South Korea) (KR)
- PDL BioPharma (United States) (US)
- Celltrion (South Korea) (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Microbiome
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1186/s40168-025-02284-7
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 22.24